Top-10 programs will face off on Wednesday in the SEC/ACC Challenge 2024 as the No. 2 Auburn Tigers visit the No. 9 Duke Blue Devils. Auburn (7-0) is coming off winning the Maui Invitational, which included a victory over an ACC school in then-No. 12 North Carolina. Meanwhile, Duke (5-2) won its last game, 70-48, versus Seattle but suffered losses to No. 1 Kansas and an SEC program in then-No. 19 Kentucky. Duke is 4-0 all-time against Auburn.

Tipoff is set for 9:15 p.m. ET from Cameron Indoor Stadium in Durham, N.C. The Blue Devils are 2.5-point favorites in the latest Auburn vs. Duke odds, while the over/under is 147.5 points per SportsLine consensus. Before entering any Duke vs. Auburn picks, you'll want to see the NCAA Basketball predictions from the model at SportsLine.

The model simulates every Division 1 college basketball game 10,000 times. It enters Week 5 of the 2024-25 season on a 170-123 roll (+2061) on all top-rated college basketball picks dating back to 2023. Anyone following has seen HUGE returns!

The model has simulated Auburn vs. Duke 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting well over 50% of the time!

So who wins Duke vs. Auburn, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks!