A 1 vs. 2 matchup will take place on Saturday night in the 2025 NCAA Tournament as the No. 1 seed Duke Blue Devils face off against the No. 2 seed Alabama Crimson Tide in the Elite Eight. A Final Four berth is on the line in this East Region contest in March Madness 2025. Duke (34-3) has won 14 straight games and is coming off a 100-93 victory over No. 4 Arizona in the Sweet 16. In that same round, Alabama (28-8) rolled over No. 6 BYU 113-88 in which the Tide made an NCAA Tournament record of 25 3-point attempts.

Tipoff from the Prudential Center in Newark, N.J., is set for 8:49 p.m. ET. The Blue Devils are 6.5-point favorites in the latest Alabama vs. Duke odds from SportsLine consensus, while the over/under for total points scored is 174.5. 

Before making any Duke vs. Alabama picks, you won't want to miss the college basketball predictions from red-hot college basketball expert Bruce Marshall.

For years, the Vegas-based Marshall was synonymous with The Gold Sheet, the famed sports betting newsletter. With a background in play-by-play work and sports information while in college, Marshall joined TGS in 1981 when hired by the legendary Mort Olshan and served as executive editor for many years. Marshall now supplies his unique and colorful brand of football and basketball analysis to SportsLine members.

Marshall enters the Elite Eight of the 2025 NCAA Tournament on a 97-68-1 roll (+2151) over his last 166 college basketball picks. Anybody who's followed his picks could be WAY UP!

For Duke vs. Alabama, Marshall is leaning Over on the total, and he also found a critical X-factor that has has him jumping on one side of the spread. You ABSOLUTELY NEED to see these picks before locking in any 2025 NCAA Tournament picks of your own.

So who wins Alabama vs. Duke, and which side of the spread should you back? Join SportsLine right now to see which side of the Duke vs. Alabama spread you need to jump on, all from a red-hot college basketball expert that is on a 97-68-1 (+2151) run over his last 166 college hoops picks!