The No. 1 seed Drake Bulldogs will try to avoid a devastating loss when they face the No. 8 seed Southern Illinois Salukis in the Missouri Valley Conference Tournament quarterfinals on Friday afternoon. Drake earned a first-round bye in Arch Madness after going 27-3 in the regular season and winning the conference by two games. Southern Illinois advanced to the quarterfinals with an 86-85 win over No. 9 seed Indiana State on Thursday afternoon. 

Tip-off is set for 1 p.m. ET on Friday at the Enterprise Center in St. Louis. Drake is favored by 10.5 points in the latest Drake vs. Southern Illinois odds, while the over/under is 127.5 points, per SportsLine consensus. 

Before entering any Drake vs. Southern Illinois picks, you'll want to see the college basketball predictions from the model at SportsLine.

The model simulates every Division 1 college basketball game 10,000 times. It enters Week 18 of the 2024-25 season on a 221-162 roll (+1895) on all top-rated college basketball picks dating back to 2023. Anyone following could have seen HUGE returns!

The model has simulated Drake vs. Southern Illinois 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that says one side of the spread is the better value!

So who wins Drake vs. Southern Illinois, and which side of the spread is the better value? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks!