The Missouri Tigers will take on the Drake Bulldogs in the first round of the 2025 NCAA Tournament on Thursday evening. Missouri (22-11) was one of 14 SEC teams to make the NCAA bracket, while Drake enters Thursday's bout with an impressive 30-3 record. The Bulldogs are 18-1 in their last 19 games, while the Tigers limp into this contest having lost four of their past six contests.

Tip-off from Intrust Bank Arena in Wichita, Kansas, is set for 7:35 p.m. ET. Missouri is a 5.5-point favorite in the latest Drake vs. Missouri odds from SportsLine consensus, while the over/under for total points scored is 133.5. 

Before making any Drake vs. Missouri picks, check out the college basketball predictions from the SportsLine Projection Model.

The model simulates every Division 1 college basketball game 10,000 times. It enters the 2025 NCAA Tournament on a 228-166 roll (+2025) on all top-rated college basketball picks dating back to 2023. This model has also produced brackets that have beaten over 91% of CBS Sports entries in four of the last six tournaments and nailed 24 first-round upsets by double-digit seeds! Anyone following could have seen HUGE returns!

The model has simulated Drake vs. Missouri 10,000 times and the results are in. We can tell you that the model is leaning Over the total, and it also says one side of the spread hits in well over 60% of simulations!

So who wins Drake vs. Missouri in the 2025 NCAA Tournament, and which side of the spread hits in well over 60% of simulations? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that is 228-166 (+2025) on top-rated college basketball pick and has nailed 24 double-digit upsets!