The Los Angeles Dodgers (1-0) and the Chicago Cubs (0-1) close out the 2025 Toyko Series on Wednesday. In Game 1 of this series, Los Angeles took down Chicago 4-1. Roki Sasaki is set to make his debut for Los Angeles in Game 2. Meanwhile, Justin Steele is on the hill for Chicago. 

First pitch is scheduled for 6:10 a.m. ET at the Tokyo Dome in Tokyo, Japan. The Dodgers are the -151 money-line favorites (bet $151 to win $100) in the latest Dodgers vs. Cubs odds, while the Cubs are +127 underdogs (bet $100 to win $127). The over/under for total runs scored is 8 in the latest MLB odds via SportsLine consensus. 

Before you make any Dodgers vs. Cubs picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.

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The model has simulated Dodgers vs. Cubs 10,000 times and the results are in. We can tell you the model is leaning Over on the run total, and it also says one side of the money line has ALL the value!

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