The Los Angeles Dodgers and Chicago Cubs meet in the MLB regular-season opening 2025 Tokyo Series on Tuesday. Los Angeles is coming off a World Series championship, while Chicago tied with St. Louis for second in the National League Central Division last year. Japanese native and right-hander Yoshinobu Yamamoto (7-2, 3.00 ERA) is the starter for the Dodgers, while the Cubs are expected to go with left-hander Shota Imanaga (15-3, 2.91 ERA), also from Japan. The Dodgers will be without Mookie Betts (illness).

First pitch is scheduled for 6:10 a.m. ET at the Tokyo Dome in Tokyo, Japan. The Dodgers are the -160 money-line favorites (bet $160 to win $100) in the latest Dodgers vs. Cubs odds, while the Cubs are +135 underdogs (bet $100 to win $135). The over/under for total runs scored is 8 in the latest MLB odds via SportsLine consensus. 

Before you make any Dodgers vs. Cubs picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters the 2025 MLB season on a 32-17 roll on top-rated run-line picks (+699) that dates back to 2023. Anybody following could have seen STRONG returns!

The model has simulated Dodgers vs. Cubs 10,000 times and the results are in. We can tell you the model is leaning Over on the run total, and it also says one side of the money line has ALL the value!

Who wins Dodgers vs. Cubs, and which side of the money line has ALL the value? ... Join SportsLine right now to find out which side of the money line you should be all over, all from the model on a 32-17 roll on top-rated MLB run-line picks!