The Arizona Diamondbacks (49-48) and the Chicago Cubs (47-51) meet on Friday afternoon, in the first game after the All-Star break. Arizona has won eight of 12, while Chicago has won eight of 11.

First pitch is scheduled for 2:20 p.m. ET from Wrigley Field in Chicago. The Cubs are the -149 money-line favorites (risk $149 to win $100) in the latest Diamondbacks vs. Cubs odds, while Arizona is a +126 underdog. The over/under for total runs scored is 7.5 in the latest MLB odds via SportsLine consensus. 

Before you make any Diamondbacks vs. Cubs picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. It entered the All-Star break of the 2024 MLB season a profitable 52-42 on all-top rated MLB picks this season. Dating back to last season, it is on a 24-10 roll on top-rated run-line picks (+977). Anybody following has seen STRONG returns!

The model knows Arizona second baseman Ketel Marte has been on fire of late. He entered the All-Star break batting .292, with 19 doubles, two triples, 19 home runs, 57 RBI and 64 runs scored. He was 1-for-3 with a run scored in Tuesday's All-Star Game. He had five multi-hit games over the last nine prior to the break, including a 3-for-5 effort with a homer, four RBI and one run scored in Sunday's 8-7 loss to the Toronto Blue Jays. He has hit Chicago pitching well in the past, batting .278 with five doubles, one triple, five homers and 14 RBI in 30 career games against the Cubs.

The model also knows first baseman Michael Busch helps lead the Chicago offense. In a 5-4 loss in Game 2 of a doubleheader at St. Louis on Saturday, he was 3-for-5 with a double. He was on a roll in the three-game sweep at Baltimore last week, going 8-for-15 (.533) with three doubles, one homer and four RBI. In 91 games this season, Busch is batting .271 with 19 doubles, one triple, 12 homers, 36 RBI and 46 runs scored.

The model has simulated Diamondbacks vs. Cubs 10,000 times and the results are in. We can tell you the model is leaning Over on the run total, and it also says one side of the money line has ALL the value!

Who wins Diamondbacks vs. Cubs, and which side of the money line has ALL the value? ... Join SportsLine right now to find out which side of the money line you should be all over, all from the model on a 24-10 roll on top-rated MLB run-line picks!