The St. John's Red Storm will host the DePaul Blue Demons for a pivotal Big East battle on Tuesday. Both teams enter Tuesday's tilt with an 8-2 record. St. John's is coming off a dominant 99-77 victory over Bryant, while DePaul defeated Wichita State 91-72 in its last outing.  

Tipoff from Carnesecca Arena is set for 6:30 p.m. ET. The Red Storm are 12.5-point favorites in the latest DePaul vs. St. John's odds from SportsLine consensus, while the over/under for total points scored is 150.5. Before entering any St. John's vs. DePaul picks, you'll want to see the college basketball predictions from the advanced computer model at SportsLine.

The model simulates every Division 1 college basketball game 10,000 times. It enters Week 7 of the 2024-25 season on a 176-128 roll (+2066) on all top-rated college basketball picks dating back to 2023. Anyone following has seen HUGE returns!

Now, the model has simulated DePaul vs. St. John's 10,000 times and the results are in. We can tell you that the model is leaning Over the total, and it's also generated a point-spread pick that hits in over 50% of simulations!

So who wins St. John's vs. DePaul, and which side of the spread hits more than 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks!