The Chicago Cubs continue their six-game road trip when they visit the National League Central-rival Pittsburgh Pirates on Wednesday for the finale of their two-game series. First pitch at PNC Park is set for 12:35 p.m. ET.

Chicago is listed as a -130 favorite (risk $130 to win $100) on the money line in the latest Cubs vs. Pirates odds from Caesars Sportsbook, while the over-under for total runs scored is 8.5 (see the latest lines for every game on our MLB odds page).

Before making any Pirates vs. Cubs picks, you NEED to see the latest MLB predictions from the SportsLine Projection Model.

This model, which simulates every game 10,000 times, entered Week 2 of the 2022 season on a 216-181 roll on top-rated MLB money-line picks that dates back to last season, returning over $900 for $100 players. Anyone following it has seen HUGE returns!

The model knows Seiya Suzuki did not disappoint in his first series with Chicago after signing a five-year, $85 million contract in March. The 27-year-old Japanese star hit safely in all three games against Milwaukee, going 3-for-8 with a homer, six RBIs, four walks and two runs scored. Suzuki will look to provide some offensive support for Kyle Hendricks, who settled for a no-decision versus the Brewers on Opening Day after giving up just one run over 5 1/3 innings.

The model also knows Zach Thompson will make his debut with Pittsburgh after being acquired from Miami during an offseason trade. The 28-year-old right-hander made two of his 14 starts as a rookie last year against the Cubs, going 0-1 despite allowing just one earned run over 10 innings. Ke'Bryan Hayes, whose eight-year, $70 million contract extension was made official on Tuesday, had a solid season-opening series against St. Louis as he went 4-for-10 with a double, an RBI and two runs scored in three contests.

Now, it has set its sights on Cubs vs. Pirates. We can tell you the model is projecting 9.8 total runs, and it also says one side of the money line has all the value! You ABSOLUTELY need to see it before locking in any MLB picks of your own.

So who wins Cubs vs. Pirates? And which side of the money line has all the value? ... Join SportsLine right now to find out which side of the Pirates vs. Cubs money line you should be all over on Wednesday, all from the model that has gone 216-181 on top-rated MLB money-line picks dating back to last season!