The Indianapolis Colts hit the road to take on the Green Bay Packers in a cross-conference matchup on the NFL Week 2 schedule. Both teams lost their season openers in Week 1. The Colts came up short against the Houston Texans, losing 29-27. The Packers fell to the Philadelphia Eagles 34-29 in the 2024 Sao Paulo Game in Brazil. Packers quarterback Jordan Love (knee) is listed as doubtful on the team's injury report due to the MCL injury he suffered in Week 1. Malik Willis is expected to start for Green Bay is Love can't go.

Kickoff is scheduled at 1 p.m. ET on Sunday at Lambeau Field. The Colts are favored by 2.5 points in the latest Packers vs. Colts odds via SportsLine consensus, and the over/under is 40.5 points. Indianapolis is the -141 money-line favorite (risk $141 to win $100), while Green Bay is the +120 underdog. Before locking in any Packers vs. Colts picks, you'll want to see the NFL predictions from the model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 2 of the 2024 NFL season on an incredible 184-130 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 38-22 roll on top-rated NFL picks since Week 7 of 2022. The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP!

The model has simulated Colts vs. Packers 10,000 times and the results are in. We can tell you that the model is leaning Over on the point total, and it's also generated a point-spread pick that is hitting in well over 50% of simulations!

So who wins Packers vs. Colts, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks!