The Detroit Lions will try to remain atop the NFC standings when they face the Indianapolis Colts on Sunday afternoon. Detroit is riding an eight-game winning streak after beating Jacksonville in a 52-6 blowout last week. Indianapolis snapped a three-game losing streak with a 28-27 win over the Jets last week, putting the Colts two games behind Houston atop the AFC South standings.  

Kickoff is set for 1 p.m. ET on Sunday at Lucas Oil Stadium. The Lions are favored by 7.5 points in the latest Colts vs. Lions odds, while the over/under is 50.5 points per SportsLine consensus. The Lions are -400 money-line favorites (risk $400 to risk $100), while the Colts are +314 underdogs (risk $100 to win $314). Before entering any Lions vs. Colts picks, you'll want to see the NFL predictions from the model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 12 of the 2024 NFL season on an incredible 20-8 hot streak on top-rated NFL picks this year. Longer term, it is on a 200-136 roll on top-rated NFL picks that dates back to the 2017 season and a 54-29 roll on top-rated NFL picks since Week 7 of 2022.

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The model has simulated Colts vs. Lions 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 50% of simulations. You can only see the pick at SportsLine.

So who wins Colts vs. Lions? And which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks.