The Colorado Buffaloes seek their second straight conference victory when they host the Stanford Cardinal in a Pac-12 matchup on Friday. Colorado (4-2, 1-2) ended its eight-game losing streak during conference play last week as they posted a 27-24 victory at Arizona State. Stanford (1-4, 0-3) looks to avoid an identical skid as it dropped its seventh consecutive Pac-12 contest last time out, falling 42-6 to Oregon. The teams have split their first 12 meetings, with the Buffaloes winning the last three. Travis Hunter is expected to play for Colorado after missing three games with a lacerated liver. 

Kickoff at Folsom Field in Boulder, Col. is set for 10 p.m. ET. The Buffaloes are 12.5-point favorites in the latest Colorado vs. Stanford odds, while the over/under for total points scored is 59.5. Colorado is a -502 favorite and Stanford is listed at +373 on the money line (see up-to-date odds for every game this week on our college football odds page).

Before you make any Stanford vs. Colorado picks or college football predictions, you NEED to see the predictions from SportsLine's proven computer model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Since its inception, it has generated a stunning profit of more than $2,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen HUGE returns.

The model knows Colorado is seeking its first five-win season since 2019 after going 1-11 last season. Junior quarterback Shedeur Sanders, the son of head coach Deion Sanders, leads the nation with 2,020 passing yards and has registered at least 348 in four of his six outings. Six different players have 14 or more receptions, with wideout Xavier Weaver topping the club with 43 for 507 yards and a pair of touchdowns.

The model also is aware that Stanford has struggled mightily against conference opponents of late, losing 17 of its last 18 matchups. The Cardinal have lost four in a row overall, allowing at least 30 points in three of the defeats. Prior to its three-game losing streak in the all-time series, Stanford recorded five consecutive victories against Colorado -- including two at Boulder in which it outscored the Buffaloes 90-10.

Now, the model has set its sights on Friday's Colorado vs. Stanford matchup. We can tell you it is leaning Under on the total, and it also says one side of the spread hits in well over 50% of simulations! You ABSOLUTELY need to see it before locking in any college football picks!

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