The Week 3 college football schedule brings an interesting mix of conference and non-conference matchups. The highlight is the SEC on CBS matchup between No. 1 Alabama and No. 11 Florida at 3:30 p.m. ET on Saturday. Caesars Sportsbook lists Alabama at -14.5 in the Week 3 college football odds. Other matchups of note include No. 22 Auburn vs. No. 10 Penn State (-6), No. 3 Oklahoma vs. Nebraska (+22) and No. 2 Georgia vs. South Carolina (+30.5).

Before making any college football picks for Week 3, be sure to see what the SportsLine Projection Model has to say. 

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of over $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 3 of the 2021 season on a 67-50 run on all top-rated college football picks. Anyone who has followed it has seen HUGE returns.

Now, it has studied the latest college football odds from Caesars (see the latest college football lines for each matchup this week on our college football odds page), simulated every single play for Week 3 of FBS college football, and the results are in. 

One of the college picks the model is high on in Week 3: No. 12 Notre Dame (-7) covers against Big Ten foe Purdue. The Fighting Irish win by double-digits in the simulations and pick up the cover in well over 50 percent of simulations, while the under 59 also hits. 

Another prediction: No. 8 Cincinnati (-3.5) covers against Indiana. The Bearcats offer a lot of value this week as they cover almost 60 percent of the time, while the under (51) is the best play in over 70 percent of simulations. 

The model has also made the call on who wins and covers in every other FBS matchup, and it is calling for a Top 25 favorite to go down HARD. You ABSOLUTELY need to see its college football picks before locking in any of your own. 

So which college football teams should you back this week? And which Top 25 team gets stunned? ... Join SportsLine now to see who wins and covers every single game, all from the model that has returned over $3,500 in profit on top-rated ATS picks over the past five-plus seasons!