Week 6 brings a huge slate of conference matchups, and perhaps the biggest is No. 4 Penn State at No. 3 Iowa. The Hawkeyes are three-point favorites in the latest Week 6 college football odds from Caesars Sportsbook. Other matchups of note include a pair of SEC on CBS showdowns -- No. 2 Georgia vs. No. 18 Auburn (+15) and No. 1 Alabama vs. Texas A&M (+18). The Red River Showdown between No. 6 Oklahoma and No. 21 Texas (+3.5) is also on Saturday. 

Before making any college football picks for those games or others in Week 6, be sure to see what the SportsLine Projection Model has to say. 

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,400 for $100 players on its top-rated college football picks against the spread. It also enters Week 6 of the 2021 season on a 12-4 run on all top-rated college football side picks. Anyone who has followed it has seen HUGE returns.

Now, it has studied the latest college football odds from Caesars (see the latest college football lines for each matchup this week on our college football odds page), simulated every single play for Week 6 of FBS college football, and the results are in. 

One of the college picks the model is high on in Week 6: No. 17 Ole Miss bounces back from its loss against Alabama and picks up the win and cover (-6) against No. 13 Arkansas. Ole Miss covers over 60 percent of the time, while the Under (66) hits in well over 70 percent of simulations.

Another prediction: No. 9 Michigan (-3) rolls to a cover at Nebraska in more than 60 percent of simulations. The Wolverines are 4-1 against the spread in their last five games, while Nebraska is just 2-18 in its last 20 games as an underdog. 

The model has also made the call on who wins and covers in every other FBS matchup, and it is calling for a national title contender to go down HARD. You ABSOLUTELY need to see its college football picks before locking in any of your own. 

So which college football teams should you back this week? And which title contender goes down HARD? ... Join SportsLine now to see who wins and covers every single game, all from the model that has returned almost $3,400 in profit on top-rated ATS picks over the past five-plus seasons!