The Week 5 college football schedule features the biggest game so far this season, as No. 4 Alabama hosts No. 2 Georgia on Saturday night at 7:30 p.m. ET. Alabama is a 2-point underdog in the Week 5 college football odds. Other ranked vs. ranked matchups on Saturday include No. 23 Kansas State (-5.5) vs. No. 20 Oklahoma State, No. 16 Notre Dame (-5) vs. No. 15 Louisville and No. 9 Penn State (-17.5) vs. No. 19 Illinois. 

No. 1 Texas is a 38.5-point favorite against Mississippi State at 4:15 p.m. ET, while No. 3 Ohio State is a 25-point road favorite at Michigan State. Longhorns quarterback Arch Manning started in place of Quinn Ewers (abdominal) in a 51-3 win over Louisiana-Monroe last week. 

Before making any college football picks for those games or others in Week 5, be sure to see what the SportsLine Projection Model has to say. 

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of well over $2,000 for $100 players on its top-rated college football picks against the spread. It is also coming off a profitable 13-9 season on top-rated spread picks. Anyone who has followed it has seen STRONG returns!

Now, it has studied the latest college football odds (see the latest college football lines for each matchup this week on our college football odds page), simulated every single play for every Week 5 game, and the results are in. 

One of the college picks the model is high on during Week 5: No. 16 Notre Dame (-4.5) picks up a double-digit win over No. 15 Louisville in a 3:30 p.m. ET matchup on Saturday, with the Fighting Irish covering in well over 60% of simulations.

Another prediction: No. 21 Oklahoma (-3) notches a comfortable road win at Auburn in a 3:30 p.m. ET kickoff on Saturday. The model has Oklahoma covering well over 60% of the time.  

The model has also made the call on who wins and covers in every other FBS matchup, and it's calling for 10 underdogs to win outright, including an upset in one of the biggest games this week!

So which college football teams should you back in Week 5, and which primetime underdog wins outright? ... Join SportsLine now to see who wins and covers every single game, all from the model that has returned well over $2,000 in profit on top-rated ATS picks since its inception! ... You've unlocked our best deal! Get your first month of SportsLine for ONLY $1 with the promo code "LEAGUE"! Join here!