The Week 4 college football schedule is loaded with four ranked vs. ranked matchups, starting with No. 22 Nebraska vs. No. 24 Illinois on Friday night. The Cornhuskers are off to a 3-0 start, which is their best start since 2016, and they are 8.5-point favorites in the Week 4 college football odds. Illinois has won its first three games as well, including a 23-17 win over then-No. 19 Kansas in Week 2. 

Saturday's slate brings games like No. 18 Michigan (+5.5) vs. No. 11 USC on CBS, No. 14 Oklahoma State (+2.5) vs. No. 12 Utah, and No. 15 Oklahoma (+7) vs. No. 6 Tennessee. No. 1 Texas jumped Georgia for the top spot in the AP poll, and the Longhorns are 44.5-point favorites against Louisiana-Monroe in the Week 4 college football spreads. 

Before making any college football picks for those games or others in Week 4, be sure to see what the SportsLine Projection Model has to say. 

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of over $2,000 for $100 players on its top-rated college football picks against the spread. It is also coming off a profitable 13-9 season on top-rated spread picks and is off to a 4-0 start on over/under picks this season. Anyone who has followed it has seen STRONG returns! 

Now, it has studied the latest college football odds (see the latest college football lines for each matchup this week on our college football odds page), simulated every single play for every Week 4 game, and the results are in. 

One of the college picks the model is high on during Week 4: UCLA (+24.5) stays well within the spread in its game at LSU in a 3:30 p.m. ET matchup on Saturday, with the Bruins covering in over 70% of simulations.

Another prediction: Florida State (-2.5) finally wins and covers the spread against California in a 7 p.m. ET kickoff on Saturday. The model has Florida State covering over 60% of the time.  

The model has also made the call on who wins and covers in every other FBS matchup, and it's calling for multiple underdogs to win outright this week!

So which college football teams should you back in Week 4, and which underdogs win outright? ... Join SportsLine now to see who wins and covers every single game, all from the model that has returned over $2,000 in profit on top-rated ATS picks since its inception! ... You've unlocked our best deal! Get your first month of SportsLine for ONLY $1 with the promo code "LEAGUE"! Join here!