The Week 2 college football schedule brings a matchup between College Football Playoff contenders, as No. 10 Michigan hosts No. 3 Texas at noon ET on Saturday in the biggest game of the week. The latest Week 2 college football odds via SportsLine consensus list the Longhorns as 7-point favorites on the road, marking the first time Michigan has been a home underdog since 2021. Texas cruised to a 52-0 win over Colorado State last week, while Michigan notched a 30-10 win against Fresno State. 

No. 24 NC State faces No. 14 Tennessee at Bank of America Stadium in Charlotte at 7:30 p.m. ET in the other ranked vs. ranked matchup in Week 2. The Vols are 9-point favorites in the Week 2 college football spreads following their 69-3 win over Chattanooga in Week 1. Other intriguing matchups this week include Tulane (+8.5) vs. No. 18 Kansas State, No. 17 Oklahoma State (-10) vs. Arkansas and No. 25 Iowa (-2.5) vs. Iowa State at 3:30 p.m. ET on CBS. 

Before making any college football picks for those games or others in Week 2, be sure to see what the SportsLine Projection Model has to say. 

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit over $2,000 for $100 players on its top-rated college football picks against the spread. It is also coming off a profitable 13-9 season on top-rated spread picks. Anyone who has followed it has seen STRONG returns! 

Now, it has studied the latest college football odds (see the latest college football lines for each matchup this week on our college football odds page), simulated every single play for every Week 2 game, and the results are in. 

One of the college picks the model is high on during Week 2: South Carolina (+9) covers against Kentucky at 3:30 p.m. ET on Saturday. The Gamecocks escaped with a 23-19 win over Old Dominion last week, using a late turnover to get past the Monarchs. Freshman quarterback LaNorris Sellers gained valuable experience in his first game as the starter, and head coach Shane Beamer should open the playbook more in Week 2. Kentucky was not able to play four quarters against Southern Miss due to lightning, and that long evening is one reason why the model has South Carolina covering in well over 50% of simulations.  

Another prediction: No. 16 Oklahoma (-27.5) easily covers the huge spread against Houston in a 7:45 p.m. ET kickoff on Saturday. The Sooners have already covered one large spread to open the season, rolling to a 51-3 win over Temple as 42.5-point favorites last week. They raced out to a 34-0 lead at halftime before letting off the gas pedal in the second half. Houston was a 3.5-point favorite in a 27-7 loss to UNLV in Week 1, so the betting market was way off on the Cougars. The model does not think a large enough adjustment has been made for this game, as Oklahoma is covering more than 60% of the time. 

The model has also made the call on who wins and covers in every other FBS matchup, and it's calling for multiple underdogs to win outright!

So which college football teams should you back in Week 2, and which underdogs win outright? ... Join SportsLine now to see who wins and covers every single game, all from the model that has returned over $2,000 in profit on top-rated ATS picks since its inception!