The Week 2 college football schedule may not feature a top-5 matchup like last week, but it does have two powerhouse programs going head-to-head in No. 1 Alabama vs. Texas. It's a rematch of the 2010 BCS Championship Game and the Crimson Tide are 20.5-point favorites in the latest Week 2 college football odds per Caesars Sportsbook. Other top matchups of the week include Florida vs. Kentucky (+5), USC vs. Stanford (+8.5) and Baylor vs. BYU (-2.5).

Before making any college football picks for those games or others in Week 2, be sure to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,500 for $100 players on its top-rated college football picks against the spread. It enters Week 2 of the 2022 college football season on a 48-37 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen HUGE returns!

Now, it has studied the latest college football odds from Caesars (see the latest college football lines for each matchup this week on our college football odds page), simulated every single play for Week 2 of FBS college football, and the results are in. 

One of the college picks the model is high on in Week 2: Iowa State (+3.5) stays within the spread on the road versus Iowa at 4 p.m. ET. The Cyclones are projected to rush for nearly 200 yards as Iowa State covers in more than 50% of simulations.

Another prediction: Pittsburgh covers as a 6-point home underdog against Tennessee in a 3:30 p.m. ET matchup on Saturday. Pitt covers well over well over 50% of the time, while the Under (65.5) hits in almost 60% of simulations. 

The model has also made the call on who wins and covers in every other FBS matchup, and it's calling for multiple outright upsets this week! You ABSOLUTELY need to see its Week 2 college football picks before locking in any of your own. 

So which college football teams should you back this week? And which favorites go down HARD? ... Join SportsLine now to see who wins and covers every single game, all from the model that has returned almost $3,500 in profit on top-rated ATS picks over the past six-plus seasons!