The Week 10 college football schedule brings one of the biggest matchups of the regular season, as No. 3 Penn State hosts No. 4 Ohio State in a Big Ten showdown on Saturday afternoon (noon ET). Penn State improved to 7-0 with a 28-13 win at Wisconsin last week, but the Nittany Lions are 3-point underdogs in the Week 10 college football odds. The other ranked vs. ranked matchup this week pits No. 20 SMU (-7) vs. No. 18 Pittsburgh on Saturday night (8 p.m. ET). 

Other matchups to keep an eye on include No. 2 Georgia (-14.5) vs. Florida in Jacksonville, No. 1 Oregon (-14.5) at Michigan (3:30 p.m. ET, CBS), and No. 13 Indiana (-7.5) at Michigan State. Elsewhere, No. 10 Texas A&M (-3) will try to remain atop the SEC standings when it travels to South Carolina. 

Before making any college football picks for those games or others in Week 10, be sure to see what the SportsLine Projection Model has to say. 

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of well over $2,000 for $100 players on its top-rated college spread football picks, and it is a sizzling 16-7 on all top-rated picks over the past five weeks of this season. Anyone following has seen STRONG returns!

Now, it has studied the latest college football odds (see the latest college football lines for each matchup this week on our college football odds page), simulated every single play for every Week 10 game, and the results are in. 

One of the college picks the model is high on during Week 10: Duke (+21) easily stays within the spread at No. 5 Miami in a noon ET matchup on Saturday, with the Blue Devils covering in well over 60% of simulations.

Another prediction: No. 20 SMU (-7) extends its five-game winning streak against No. 18 Pittsburgh in an 8 p.m. ET kickoff on Saturday. The model has the Mustangs covering well over 60% of the time. 

The model has also made the call on who wins and covers in every other FBS matchup, and it's calling for seven underdogs to win outright!

So which college football teams should you back in Week 10, and which underdogs win outright? ... Join SportsLine now to see who wins and covers every single game, all from the model that has returned well over $2,000 in profit on top-rated ATS picks since its inception! ... You've unlocked our best deal! Get your first month of SportsLine for ONLY $1 with the promo code "LEAGUE"! Join here!