The Week 10 college football schedule starts off with five MACtion games early in the week, and then action on Thursday, Friday and Saturday. Matchups of note include LSU at No. 2 Alabama (-28.5 at Caesars Sportsbook), No. 5 Ohio State at Nebraska (+15) and No. 13 Auburn at No. 14 Texas A&M (-4.5) in the 3:30 p.m. ET SEC on CBS matchup.

Before making any college football picks for those games or others in Week 10, be sure to see what the SportsLine Projection Model has to say. 

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Week 10 of the 2021 season on a 28-15 run on all top-rated college football side picks. Anyone who has followed it has seen HUGE returns.

Now, it has studied the latest college football odds from Caesars (see the latest college football lines for each matchup this week on our college football odds page), simulated every single play for Week 10 of FBS college football, and the results are in. 

One of the college picks the model is high on in Week 10: No. 4 Oregon easily covers as a seven-point favorite at Washington in a 7:30 p.m. ET kickoff on Saturday. The Ducks cover in almost 60 percent of simulations, while the under (51) is a good bet as well because it hits almost 60 percent of the time.

Another prediction: Clemson (-4) covers at Louisville in another 7:30 p.m. ET Saturday start. Quarterback D.J. Uiagalelei throws for almost 250 yards in the simulations as the Tigers cover almost 60 percent of the time.

The model has also made the call on who wins and covers in every other FBS matchup, and it is calling for a Top 25 team to go down HARD in an upset. You ABSOLUTELY need to see its college football picks before locking in any of your own. 

So which college football teams should you back this week? And which Top 25 team gets STUNNED? ... Join SportsLine now to see who wins and covers every single game, all from the model that has returned almost $3,700 in profit on top-rated ATS picks over the past five-plus seasons!