After 11 games took place on Aug. 27, every team will be in action during the Week 1 college football schedule. Games will take place from Thursday through Monday, with all 25 ranked teams in action, including three matchups of ranked teams. The headline contest will be Notre Dame vs. Ohio State as both teams bring top-5 rankings into their 7:30 p.m. ET kickoff on Saturday night. The No. 2 Buckeyes are 17.5-point favorites over the No. 5 Irish in the latest Week 1 college football odds per Caesars Sportsbook. Other key matchups include Georgia vs. Oregon on Saturday and Clemson vs. Georgia Tech on Labor Day.

Before making any college football picks for those games or others in Week 1, be sure to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,600 for $100 players on its top-rated college football picks against the spread. It enters Week 1 of the 2022 college football season on a 45-32 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen HUGE returns!

Now, it has studied the latest college football odds from Caesars (see the latest college football lines for each matchup this week on our college football odds page), simulated every single play for Week 1 of FBS college football, and the results are in. 

One of the college picks the model is high on in Week 1: Florida (+2.5) easily stays within the spread at home versus No. 7 Utah at 7 p.m. ET. The Gators will ride the arm and legs of QB Anthony Richardson who is projected to account for over 300 yards as Florida covers in nearly 60% of simulations.

Another prediction: Louisville goes on the road and easily covers as a 5-point favorite against Syracuse in an 8 p.m. ET matchup on Saturday. Louisville covers well over 60% of the time, while the Under (56.5) hits in almost 60% of simulations. 

The model has also made the call on who wins and covers in every other FBS matchup, and it's calling for multiple outright upsets this week! You ABSOLUTELY need to see its Week 1 college football picks before locking in any of your own. 

So which college football teams should you back this week? And which favorites go down HARD? ... Join SportsLine now to see who wins and covers every single game, all from the model that has returned almost $3,600 in profit on top-rated ATS picks over the past six-plus seasons!