The 2022 college football season kicks off on Saturday, August 27 with what has been coined Week 0. There are 11 games on the Week 0 college football schedule, highlighted by Nebraska vs. Northwestern, in which the Cornhuskers are 11-point favorites per Caesars Sportsbook. Other anticipated matchups include 14-point favorite Illinois vs. Wyoming, as well as Vanderbilt being a 9-point favorites over Hawaii in the latest Week 0 college football odds.

Before making any college football picks for those games or others in Week 0, be sure to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six years, the proprietary computer model has generated a stunning profit of almost $3,600 for $100 players on its top-rated college football picks against the spread. It also finished the 2021-22 college football season on a 43-31 run on all top-rated college football side picks. Anyone who has followed it has seen HUGE returns!

Now, it has studied the latest college football odds from Caesars (see the latest college football lines for each matchup this week on our college football odds page), simulated every single play for Week 0 of FBS college football, and the results are in. 

One of the college picks the model is high on in Week 0: Wyoming (+14) easily stays within the spread on the road at Illinois in a 4 p.m. ET matchup on Saturday. The Cowboys have a knack for playing better in non-conference games than within the Mountain West as they have a 9-1 straight-up record over their last 10 non-conference contests. The SportsLine's model says they cover in 60% of simulations.

The model has also made the call on who wins and covers in every other FBS matchup, and it's calling for a HUGE outright upset this week! You ABSOLUTELY need to see its college football picks before locking in any of your own. 

So which college football teams should you back this week? And which big favorite goes down HARD? ... Join SportsLine now to see who wins and covers every single game, all from the model that has returned almost $3,600 in profit on top-rated ATS picks over the past six seasons!