All eyes will be on Columbus on Saturday. Ohio State will host Indiana at noon ET, with the winner likely earning a spot in the Big Ten title game against Oregon. Ohio State is a true perennial contender, even if Ryan Day still hasn't quite been able to finish off the job. Indiana, on the other hand, is an upstart, a typically hapless program that's sped into contention under new head coach Curt Cignetti. The Hoosiers' schedule has been light, but going 10-0 commands respect. Now it's time to see if they can hang with the blue bloods (see college football odds here). 

Elsewhere, Notre Dame faces a serious threat to its College Football Playoff aspirations when it hosts undefeated Army, and Colorado has a potential trap game on its hands as it visits an underrated and possibly unlucky Kansas team that just knocked off BYU.

The latest Week 13 college football odds via SportsLine consensus list Ohio State as a 10.5-point favorite at home over Indiana (O/U 52.5). Notre Dame is favored by 14 points against Army and Colorado is a 2.5-point favorite on the road against Kansas. 

Before making any Week 13 college football picks, be sure to check out the Week 13 college football predictions from our proven CFB expert Thomas Casale.

A frequent guest on national radio and TV shows to discuss college sports, Casale has been betting -- and winning -- for more than 30 years. 

Over the past two college football seasons, Casale is 122-92-5 (57%) overall and 26-8 (76.4%) in bowl games -- all publicly documented. Just last week, Casale backed Air Force at +4.5 against Oregon State, noting that the Falcons have been trending up. Air Force vaporized the Beavers 28-0.

Now, he's turned his attention to the 2024 Week 13 college football odds (see the latest college football lines for each game this week on our college football odds page) and is revealing his top plays.

We can tell you Casale is once again backing Air Force (+3), this time against Nevada. He notes that the Wolf Pack have dropped four straight games by an average of 14 points.

Casale has also found two other college football picks he loves, including a must-see play on the Indiana-Ohio State game! You ABSOLUTELY need to see what he's playing before locking in any college football picks.

What are Casale's best bets for Week 13 in the 2024 college football season, and which lines should you jump on now? ... Join SportsLine right now to see Thomas Casale's best bets, all from one of the top college football handicappers in the nation!