While Week 10 of the college football season doesn't have the usual plethora of ranked-on-ranked matchups, there are still plenty of intriguing games. There's none bigger than Saturday's noon showdown between No. 4 Oho State and No. 3 Penn State (+3), of course, but other matchups worth noting, including No. 18 Pitt at No. 20 SMU, Wisconsin at Iowa, Duke at No. 5 Miami, and No. 19 Ole Miss at Arkansas (see college football odds here). 

Before you make any Week 10 college football predictions, be sure to check out the Week 10 college football picks from our proven CFB expert Thomas Casale.

A frequent guest on national radio and TV shows to discuss college sports, Casale has been betting -- and winning -- for more than 30 years. 

Over the past two college football seasons, Casale is 122-92-5 (57%) overall and 26-8 (76.4%) in bowl games -- all publicly documented. Just last week, Casale advised SportsLine members to back Boston College at +7.5 against Louisville. The Eagles kept the game close and lost 31-27, covering in the process. 

Now, he's turned his attention to the 2024 Week 10 college football odds (see the latest college football lines for each game this week on our college football odds page) and is revealing his top plays.

We can tell you Casale is backing Iowa (-3) over Wisconsin on Saturday at 7:30 p.m. ET. The Badgers simply don't have a passing game to threaten defenses down the field, so it's imperative they move the football on the ground," Casale says. "That won't be an easy task on Saturday. Iowa ranks 22nd at defending the run and allows just over 70 rushing yards per game at home."

Casale has also found two other college football picks he loves, including a must-see play on a huge underdog! You ABSOLUTELY need to see what he's playing before locking in any college football picks.

What are Casale's best bets for Week 10 in the 2024 college football season, and which lines should you jump on now? ... Join SportsLine right now to see Thomas Casale's best bets, all from one of the top college football handicappers in the nation!