The Syracuse Orange will kick off their ACC slate when they take on the Clemson Tigers on Saturday. The Orange are looking to start 5-0 for the second consecutive season and for the third time since 1987. Syracuse defeated Army 29-16 last week, while Clemson dropped a 31-24 overtime thriller to fourth-ranked Florida State. 

Kickoff is set for noon ET on Saturday at JMA Wireless Dome in Syracuse, N.Y. Clemson is favored by 7 points in the latest Clemson vs. Syracuse odds, while the over/under is set at 53 points, per SportsLine consensus. Clemson is -268 on the money line, while Syracuse is +230.

Before entering any Clemson vs. Syracuse picks, you NEED to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Since its inception, it has generated a stunning profit of nearly $2,500 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen HUGE returns.

The model knows Clemson sophomore quarterback Cade Klubnik is off to a fast start to his season, completing 96 of 145 passes (66.2%) for 976 yards and nine touchdowns with two interceptions. He has also carried 36 times for 73 yards (2.0 average) and two touchdowns. Klubnik completed 25 of 38 passes (65.8%) for 283 yards and one touchdown in last week's loss to fourth-ranked Florida State.

It also is aware senior quarterback Garrett Shrader leads the Syracuse offense, completing 72 of 108 passes (66.7%) for 972 yards and six touchdowns against three interceptions. He also is the team's top rusher, carrying 46 times for 316 yards (6.9 average) with six touchdowns. Shrader rushed for four touchdowns at Purdue on Sept. 16, and is coming off a 21 of 26 passing performance for 245 yards and one touchdown in the win over Army.

The model has simulated Clemson vs. Syracuse 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in well over 50% of simulations. You can only see the pick at SportsLine.

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