The No. 20 Clemson Tigers square off against the Pittsburgh Panthers in an ACC showdown on Saturday. The Tigers are coming off a 24-14 victory over Virginia Tech after suffering a disappointing loss at home against Louisville. Pitt, meanwhile, has lost two straight after opening the season 7-0. Pitt quarterback Eli Holstein (head) is reportedly out. 

Kickoff from Acrisure Stadium in Pittsburgh is set for noon ET. The Tigers are 12.5-point favorites according to the latest Clemson vs. Pittsburgh odds via SportsLine consensus, while the over/under for total points scored is 49.5.

Before locking in any Pittsburgh vs. Clemson picks, you'll want to see the college football predictions from the advanced computer model at SportsLine.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of well over $2,000 for $100 players on its top-rated college spread football picks, and it is a strong 18-12 on all top-rated picks over the past seven weeks of this season. Anyone following has seen STRONG returns!

Now, the model has set its sights on Clemson vs. Pitt on Saturday. We can tell you it is leaning Over the total, projecting 56 combined points. It also says one side of the spread hits in nearly 60% of simulations!

So who wins Clemson vs. Pittsburgh, and which side of the spread hits nearly 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that is up well over $2,000 on top-rated CFB spread picks!