An ACC battle is on tap between the Louisville Cardinals and the Clemson Tigers at 7:30 p.m. ET on Saturday, Nov. 6 at Cardinal Stadium. U of L is 4-4 overall and 3-1 at home, while Clemson is 5-3 overall and 1-2 on the road. 

The Tigers are favored by 3.5 points in the latest Louisville vs. Clemson odds from Caesars Sportsbook, and the over-under is set at 46.5. Before you make any Clemson vs. Louisville picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Week 10 of the 2021 season on a 28-15 run on all top-rated college football side picks. Anyone who has followed it has seen HUGE returns.

Now, it has simulated Louisville vs. Clemson 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in over 60 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Louisville vs. Clemson? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks.