The No. 11 Clemson Tigers look to make their way back into the top 10 in the polls and keep pace atop the ACC standings when they play the Louisville Cardinals in ACC action on Saturday night. Clemson improved to 6-1 overall and 5-0 in the ACC with a 48-31 win over Virginia on Oct. 19 before a bye last week. Louisville improved to 5-3 overall and 3-2 in the ACC with a 31-27 victory over Boston College on Oct. 25. The Cardinals outscored Boston College, 14-0, in the fourth quarter in the comeback victory and hope to carry that momentum to upset a ranked Clemson squad.

Kickoff is set for 7:30 p.m. on Saturday from Memorial Stadium, also known as Death Valley, in Clemson, S.C. The Tigers are 10.5-point favorites in the latest Louisville vs. Clemson odds, while the over/under is 62 points, per SportsLine consensus. 

Before entering any Clemson vs. Louisville picks, you'll want to see the college football predictions from the model at SportsLine.

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The model has simulated Louisville vs. Clemson 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that hits in almost 60% of simulations!

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