The 2025 ACC Tournament continues Friday when the No. 2 seed Louisville Cardinals play the No. 3 seed Clemson Tigers. Louisville, ranked No. 13 in the nation, is 26-6 overall, including 18-2 in the ACC. Clemson, ranked No. 10 in the country, is 27-5 overall and 18-2 in conference. 

Tipoff is set for 9:30 p.m. on Friday from the Spectrum Center in Charlotte, N.C. Clemson is a 1.5-point favorite in the latest Louisville vs. Clemson odds, while the over/under is 141.5 points per SportsLine consensus. The Tigers are -124 (risk $124 to win $100) money-line favorites, while the Cardinals are +104 (risk $100 to win $104) underdogs.

Before entering any Clemson vs. Louisville picks, you'll want to see the college basketball predictions from the model at SportsLine.

The model simulates every Division 1 college basketball game 10,000 times. It enters conference championship week on a 225-165 roll (+1873) on all top-rated college basketball picks dating back to 2023. Anyone following could have seen HUGE returns!

The model has simulated Louisville vs. Clemson 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread covers in well over 60% of simulations!

So who wins Clemson vs. Louisville, and which side of the spread covers well over 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks!