A star-studded showdown takes place when the No. 4 Kentucky Wildcats take on the Clemson Tigers in the 2024 ACC/SEC Challenge on Tuesday night. Kentucky is coming off a 105-76 win over Georgia State on Friday, while Clemson cruised to an 86-58 victory against Florida A&M 86-58 the same day. 

Tipoff from Littlejohn Coliseum is at 9:30 p.m. ET. The Wildcats are 2-point favorites in the latest Kentucky vs. Clemson odds via SportsLine consensus, while the over/under for total points scored is 158.5. Before entering any Clemson vs. Kentucky picks, you'll want to see the NCAA Basketball predictions from the model at SportsLine.

The model simulates every Division 1 college basketball game 10,000 times. It enters Week 5 of the 2024-25 season on a 170-123 roll (+2061) on all top-rated college basketball picks dating back to 2023. Anyone following has seen HUGE returns!

Now, the model has simulated Kentucky vs. Clemson 10,000 times and the results are in. We can tell you that the model is leaning Over the total, and it also says one side of the spread is the better value.

So who wins Kentucky vs. Clemson, and which side of the spread is the better value? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks!