The No. 2 Duke Blue Devils will try to extend their 16-game winning streak when they face the Clemson Tigers in an ACC battle on Saturday night. Duke holds a two-game lead over Clemson and Louisville atop the ACC standings, jumping out to a 12-0 start in league play. Clemson had its six-game winning streak snapped in a triple-overtime loss to Georgia Tech on Tuesday.  

Tipoff is set for 6:30 p.m. ET on Saturday at Littlejohn Coliseum. Duke is favored by 7 points in the latest Clemson vs. Duke odds, while the over/under is 133.5 points, per SportsLine consensus. Before entering any Duke vs. Clemson picks, you'll want to see the college basketball predictions from the model at SportsLine.

The model simulates every Division 1 college basketball game 10,000 times. It enters Week 14 of the 2024-25 season on a 208-149 betting roll (+2275) on all top-rated college basketball picks dating back to 2023. Anyone following at sportsbooks and on betting apps could have seen huge returns.

The model has simulated Clemson vs. Duke 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 50% of simulations. You can only see the pick at SportsLine.

So who wins Clemson vs. Duke? And which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks.