The San Francisco 49ers (3-3) will host the Kansas City Chiefs (4-2) on Sunday. Kickoff is set for 4:25 p.m. ET from Levi's Stadium. Kansas City is a 1-point favorite in the latest Chiefs vs. 49ers odds from Caesars Sportsbook, and the over/under for total points scored is 49. The Niners acquired Christian McCaffrey from the Panthers on Thursday and he could make his San Francisco debut in this one.

Before making any Chiefs vs. 49ers picks of your own, you NEED to check out the NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 7 of the 2022 NFL season on an incredible 146-107 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP.

The model knows Kansas City has one of the top offenses in the league. This unit is led by quarterback Patrick Mahomes, who is one of the best at his position. Mahomes has an uncanny ability to improvise and create magical plays outside of the pocket. The four-time Pro Bowl selection is third in passing yards (1,736) and tied for first in passing touchdowns (17). 

The model also knows San Francisco has been playing shutdown defense to kick off the year. The 49ers are ranked first in the NFL in yards allowed per game (255.8) and second in passing yards allowed (168.3) and rushing yards allowed (87.5). Linebacker Dre Greenlaw is leading the squad in total tackles (55) with three tackles for loss.

Now, the model has set its sights on Chiefs vs. 49ers in Week 7. We can tell you the model is leaning Under the total, and it also says one side of the spread cashes well over 50% of the time! You ABSOLUTELY need to see it before locking in any NFL picks.

So who wins Chiefs vs. 49ers? And which side of the spread hits well over 50% of the time? Join SportsLine now to see which side of the Chiefs vs. 49ers spread to back, all from the model that's an amazing 146-107 on NFL picks!