AFC West meets NFC West in Week 12 as the Arizona Cardinals host the Los Angeles Chargers on Sunday on CBS and Paramount+. Kickoff from University of Phoenix Stadium in Glendale, Arizona is set for 4:05 p.m. ET. The Chargers are 2.5-point favorites in the latest Cardinals vs. Chargers odds from Caesars Sportsbook, and the over/under for total points is 48.5. Sunday's showdown will be streamed live in select markets on Paramount+ with their MUST-HAVE Premium plan, which you can try for 50% off your first year with promo code ALLYEAR (expires 12/31/22).

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Before making any Cardinals vs. Chargers picks or any other NFL predictions, you NEED to see what the SportsLine Projection Model has to say.

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 12 of the 2022 NFL season on an incredible 155-109 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP.

Now, it has simulated Cardinals vs. Chargers 10,000 times and the results are in. We can tell you that the model is leaning Over on the total, and it also says one side of the spread cashes in well over 50% of simulations! You ABSOLUTELY need to see it before locking in your own picks. And don't forget you may be able to stream the game on Paramount+ on ANY DEVICE!

Who wins Chargers vs. Cardinals? And which side of the spread hits well over 50% of the time? ... Join SportsLine right now to see which side of the Chargers vs. Cardinals spread to jump on, all from the model that has crushed its NFL picks!