The Los Angeles Chargers (4-2) and Arizona Cardinals (2-4) will meet in the second half of a Monday Night Football doubleheader to close out Week 7. The Chargers are fresh off a 23-16 win over the Denver Broncos last Sunday. Also a week ago, the Cardinals were dominated by the Green Bay Packers, 34-13. 

Kickoff from State Farm Stadium in Glendale is set for 9 p.m. ET. The Chargers are 1.5-point favorites in the latest Chargers vs. Cardinals odds from SportsLine Consensus, while the over/under for total points scored is 44. The Chargers are -120 money-line favorites (risk $120 to win $100), while the Cardinals are +100 underdogs. Before making any Chargers vs. Cardinals picks, you NEED to see the NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 7 of the 2024 NFL season on an incredible 11-3 hot streak on top-rated NFL picks this year. Longer term, it is on a 192-132 roll on top-rated NFL picks that dates back to the 2017 season and a 46-24 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP!

The model has simulated Chargers vs. Cardinals 10,000 times and the results are in. We can tell you the model is leaning Over the point total, and it also says one side of the spread cashes in nearly 60% of simulations!

Who wins Chargers vs. Cardinals on Monday Night Football, and which side of the spread cashes almost 60% of the time? ... Join SportsLine right now to find out which side of the Chargers vs. Cardinals spread you should be all over, all from the model that is up well over $7,000 on its NFL picks!