The Boston Celtics and Portland Trail Blazers will play for the first time this season tonight in Boston after the Celtics have swept the season series in each of the previous two years. The Celtics are second in the Eastern Conference at 43-18 overall, including 19-11 at home this season. The Trail Blazers (28-34) are four games out of the final spot in the NBA Play-In Tournament, but they've been playing some of their best basketball of the season over their current road trip. Portland is 4-1 in the middle of a seven-game road trip entering Wednesday. Jayson Tatum (shoulder) and Jaylen Brown (illness) are questionable for Boston, while Jerami Grant (knee) is questionable for Portland.

Tip-off is set for 7 p.m. ET from TD Garden in Boston, Mass. This is the first matchup of the season between the two, but the Celtics have won each of the last four meetings between the teams. The Celtics are favored by 9.5 points in the latest Blazers vs. Celtics odds, according to the SportsLine consensus, while the over/under is 225 points. The Celtics are at -412 on the money line (risk $412 to win $100), with the Blazers at +320 (risk $100 to win $320). Before entering any Blazers vs. Celtics picks, you'll want to see the NBA predictions from the model at SportsLine.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit for $100 players on its top-rated NBA picks over the past six-plus seasons. The model enters Week 20 of the 2024-25 NBA season on a sizzling 147-107 roll on all top-rated NBA picks dating back to last season, returning nearly $4,000. It's also an outstanding 18-10 (64%) on top-rated spread picks this season. Anyone following could have seen HUGE returns!

The model has simulated Blazers vs. Celtics 10,000 times and the results are in. We can tell you that the model is leaning Under, and it also says one side of the spread hits well over 50% of the time!

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