The Boston Celtics and New York Knicks open their 2021-22 campaigns with an Eastern Conference matchup at 7:30 p.m. ET on Wednesday. New York is favored by 1.5-points at Caesars Sportsbook, while the Over-Under is set at 216.5 (see up-to-date odds for every game this week on our NBA odds page). Before making any Celtics vs. Knicks picks, you NEED to check out the NBA predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned almost $9,000 in profit on its top-rated NBA picks over the past three seasons. The model finished up almost $600 on its top-rated picks last season and enters the 2021-22 NBA season on a stunning 100-66 roll on top-rated NBA picks against the spread. Anyone following it has seen HUGE returns!

The model knows the Celtics are blessed with a pair of top-tier forwards in Jayson Tatum and Jaylen Brown. Tatum averaged 26.4 points and 7.4 rebounds per game last season, with Brown adding 24.7 points and 6.0 rebounds per contest. Boston is also a very strong three-point shooting team (37.4 percent a year ago), and the Celtics project to be very solid defensively. The Celtics wall off the paint, allowing only 44.3 points in the paint per game last season, and Boston can also take advantage of a Knicks offense that ranked outside the top 20 in the NBA in 2020-21.

The model also knows the Knicks are excellent defensively under Tom Thibodeau. New York was a top-five team in the NBA last season in defensive efficiency, leading the entire league in field goal percentage allowed (44 percent) and three-point percentage allowed (33.7 percent). Boston was also a below-average team in free throw creation, field goal percentage and assists last season, and the Celtics will be without newly acquired big man Al Horford in the opener.

Now, it has set its sights on Celtics vs. Knicks. We can tell you the model is leaning under the total, and it also says one side of the spread hits in over 60 percent of simulations! You ABSOLUTELY need to see it before locking in any NBA picks.

Who wins Celtics vs. Knicks? And which side of the spread hits in over 60 percent of simulations? ... Join SportsLine right now to find out which side of the Celtics vs. Knicks spread you should be all over Wednesday, all from the model on a roll on NBA picks!