The New York Knicks hit the road looking to win their fourth straight game when they take on the Cleveland Cavaliers on Wednesday. Cleveland is 60-15 overall and 32-5 at home, while New York is 48-27 overall and 22-15 on the road. The Knicks are coming off a 105-91 win over the Philadelphia 76ers. The Cavaliers own the best record in the Eastern Conference, and will be looking to build off their 127-122 win over the Los Angeles Clippers. Jalen Brunson (ankle) and Mitchell Robinson (ankle) are out for New York.

Tip-off from Rocket Arena in Cleveland, is set for 7 p.m. ET. The Cavs are 10.5-point favorites in the latest Knicks vs. Cavaliers odds from SportsLine consensus, while the over/under is 230.5 points. The Cavs are at -495 on the money line (risk $495 to win $100), while New York is at +375 (risk $100 to win $375). Before making any Knicks vs. Cavaliers picks, you'll want to check out the NBA predictions and betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit for $100 players on its top-rated NBA picks over the past six-plus seasons. The model enters Week 24 of the 2024-25 NBA season on a sizzling 155-115 roll on all top-rated NBA picks dating back to last season, returning nearly $4,000. It's also an outstanding 21-10 (68%) on top-rated spread picks this season. Anyone following could have seen HUGE returns!

The model has simulated Knicks vs. Cavaliers 10,000 times and the results are in. We can tell you that the model is leaning Under on the point total, and it also says one side of the spread hits in well over 50% of computer simulations.

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