The Cleveland Cavaliers (19-12) and the Boston Celtics (15-16) face off in an Eastern Conference matchup on Wednesday night at 7:30 p.m. ET. Boston is favored by 6.5 points in the latest Cavaliers vs. Celtics odds from Caesers Sportsbook, while the Over-Under is set at 216.5 (see up-to-date odds for every game this week on our NBA odds page). 

Before making any  Cavaliers vs. Celtics picks, you NEED to check out the NBA predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit on its top-rated NBA picks over the past three-plus seasons. The model enters Week 10 of the 2021-22 NBA season on a stunning 46-23 roll on all top-rated NBA picks, returning almost $1,900. Anyone following it has seen HUGE returns.

The model knows Celtics forward Jayson Tatum is eighth in the NBA in points per game (25.9) while coming down with 8.6 boards and 3.7 assists. The 2017 third-overall pick has scored 30-plus in 10 games thus far. His best outing came in a win against the Milwaukee Bucks. Tatum dropped 42 points, five rebounds, four assists, along with three steals. The Duke product knocked down a season-high seven 3-pointers.

The model also knows Cavaliers point guard Darius Garland is first on the team in points (19.1) and assists (7.3). The Vanderbilt product has taken a step in his third season. He has scored over 20 points 12 times thus far, including back-to-back 30-point performances. In a win against the Washington Wizards on Dec. 3, Garland finished with a season-high 32 points, eight rebounds, and 10 assists. He was also an efficient 5 of 6 from downtown. 

Now, it has set its sights on Cavaliers vs. Celtics. We can tell you the model is leaning under the total and it also says one side of the spread hits in almost 70 percent of simulations! You ABSOLUTELY need to see it before locking in any NBA picks.

Who wins Cavaliers vs. Celtics? And which side of the spread hits in almost 70 percent of simulations? ... Join SportsLine right now to find out which side of the Cavaliers vs. Celtics spread you should be all over Wednesday, all from the model on a roll on NBA picks!