The St. Louis Cardinals will battle the Pittsburgh Pirates in a key National League Central Division matchup on Wednesday afternoon. The Cardinals (5-6), who snapped a four-game losing streak, are 1-4 on the road this season. The Pirates (4-8), who have won two of three, are 2-3 on their home field.

First pitch from PNC Park in Pittsburgh is set for 12:35 p.m. ET. St. Louis is a -116 favorite on the money line (risk $116 to win $100) in the latest Cardinals vs. Pirates odds from SportsLine consensus, while the total number of runs Vegas thinks will be scored, or the over/under, is 7.5.

Before making any Cardinals vs. Pirates picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters the 2025 MLB season on a 34-19 roll on top-rated run-line picks (+629) that dates back to 2023. Anybody following could have seen strong returns. 

The model knows St. Louis is expected to send right-hander Erick Fedde (1-1, 7.00 ERA) to the mound. In his first outing, a 5-1 win over the Minnesota Twins on March 29, he was solid, picking up the win and pitching six innings, allowing two hits, one earned run with no walks and two strikeouts. He took the loss in a 13-9 defeat at Boston on Friday. He has pitched well against Pittsburgh in the past. In three career starts against the Pirates, he is 1-0 with a 2.81 ERA.  

The model also knows Pittsburgh will counter with right-hander Mitch Keller (1-1, 7.45 ERA). In his first outing this year, a 4-3 win at Miami on March 28, he pitched six innings, allowing one earned run and one walk, while striking out four. In 31 starts a year ago, Keller was 11-12 with a 4.25 ERA, allowing 182 hits, 84 earned runs and 50 walks with 166 strikeouts in 178 innings. In 13 career starts against St. Louis, he is 2-3 with a 3.72 ERA.

The model has simulated Cardinals vs. Pirates 10,000 times and the results are in. We can tell you the model is leaning Over on the run total, and it also says one side of the money line has ALL the value!

Who wins Cardinals vs. Pirates, and which side of the money line has ALL the value? ... Join SportsLine right now to find out which side of the money line you should be all over, all from the model on a 34-19 roll on top-rated MLB picks!