The No. 6 seed BYU Cougars look to continue their march toward their first-ever Final Four appearance when they battle the No. 2 seed Alabama Crimson Tide in the East Region Sweet 16 matchup Thursday. The Cougars (26-9), who are 17-31 in 32 NCAA Tournament appearances, last advanced past the first round in 2012. The Crimson Tide (27-8), who are 31-25 in 26 tournament appearances, reached the Final Four for the first time in program history last year.

Tipoff from Prudential Center in Newark, N.J., is set for 7:09 p.m. ET. Alabama is a 5.5-point favorite in the latest BYU vs. Alabama odds from SportsLine consensus, while the over/under for total points scored is 175.5. 

Before making any BYU vs. Alabama picks, check out the college basketball predictions from the SportsLine Projection Model.

The model simulates every Division 1 college basketball game 10,000 times. It enters the 2025 NCAA Tournament on a 228-168 roll (+1815) on all top-rated college basketball picks dating back to 2023. This model has also produced brackets that have beaten over 91% of CBS Sports entries in four of the last six tournaments and has nailed 25 first-round upsets by double-digit seeds! Anyone following could have seen HUGE returns!

The model has simulated BYU vs. Alabama 10,000 times and the results are in. We can tell you that the model is leaning Under, and it also says one side of the spread hits in more than 60% of simulations!

So who wins BYU vs. Alabama, and which side of the spread hits in more than 60% of simulations? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that is 228-168 (+1815) on top-rated college basketball pick and has nailed 25 first-round upsets by double-digit seeds!