We've got another exciting Central Division matchup on the Wednesday NBA schedule as the Chicago Bulls are set to host the Detroit Pistons at the United Center. Chicago is 22-32 overall and 10-18 at home, while Detroit is 28-26 overall and 14-13 on the road. These teams also played on Tuesday night, with the Pistons winning 132-92. The Pistons are 29-24-1 and the Bulls are 23-29-2 against the spread this season. Jaden Ivey (leg) is out for the Pistons.

Tipoff in Chicago is at 8 p.m. ET. The Pistons are favored by 6.5 points in the latest Bulls vs. Pistons odds from SportsLine consensus, and the over/under is 236.5 points. Before entering any Bulls vs. Pistons picks, you'll want to see the NBA predictions and betting advice from the proven computer simulation model at SportsLine.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past six-plus seasons. The model enters Week 16 of the 2024-25 NBA season on a sizzling 144-102 roll on all top-rated NBA picks dating back to last season, returning nearly $4,000. Anyone following at sportsbooks and on betting apps could have seen huge returns.

The model has simulated Bulls vs. Pistons 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in well over 50% of simulations. You can only see the model's pick at SportsLine.

So who wins Bulls vs. Pistons? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NBA picks.