The Cleveland Browns will take on the Arizona Cardinals at 4:05 p.m. ET on Sunday at FirstEnergy Stadium. The Browns are 3-2 overall and 2-0 at home, while Arizona is 5-0 overall and 3-0 on the road. 

Cleveland is favored by three-points in the latest Browns vs. Cardinals odds from Caesars Sportsbook, and the over-under is set at 48. Before you make any Cardinals vs. Browns picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six-plus years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters Week 6 of the 2021 season on an incredible 125-83 run on top-rated NFL picks that dates back to the 2017 season. The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY up.

Now, it has simulated Browns vs. Cardinals 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Browns vs. Cardinals? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks... If you're already a member, see the picks below!