The San Francisco 49ers will take their perfect record on the road for a meeting with the Cleveland Browns on Sunday afternoon. San Francisco improved to 5-0 with its 42-10 win against Dallas last week, wrapping up a perfect three-game homestand. Cleveland lost to Baltimore two weeks ago before having the week off last Sunday. 

Kickoff is set for 1 p.m. ET on Sunday at Cleveland Browns Stadium. San Francisco is favored by 9.5 points in the latest 49ers vs. Browns odds from the SportsLine consensus, while the over/under is 36 points. Before entering any 49ers vs. Browns picks, you NEED to see the NFL predictions from the model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 5 of the 2023 NFL season on an incredible 171-119 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 25-11 roll on top-rated NFL picks since Week 7 of last season. 

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP!

The model has simulated Browns vs. 49ers 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick where one side has all of the value. You can only see the pick at SportsLine.

So who wins 49ers vs. Browns, and which side of the spread has all of the value? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that is on a 171-119 run on NFL picks. If you're already a member, see the picks below!