The Milwaukee Brewers battle the New York Yankees in a Major League Baseball season opener on Thursday afternoon. The Brewers, who have won the National League Central each of the past two seasons, were 46-35 on the road in 2024. The Yankees, who won the AL East in two of the past three years, were 44-37 at home last season.

First pitch at Yankee Stadium is set for 3:05 p.m. ET. New York is a -144 favorite on the money line (risk $144 to win $100) in the latest Brewers vs. Yankees odds, while the total number of runs Vegas thinks will be scored, or the over/under, is 8, in the latest MLB odds via SportsLine consensus. The Brewers are -135 favorites to score the first run. 

Before making any Brewers vs. Yankees picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters the 2025 MLB season on a 32-17 roll on top-rated run-line picks (+699) that dates back to 2023. Anybody following could have seen strong returns. 

The model knows New York is led by  center fielder Aaron Judge. In 158 games in 2024, he batted .322 with 36 doubles, one triple, 58 homers, 122 runs scored and 144 RBI. In limited action, he has hit Milwaukee well. In 12 games against the Brewers, he is hitting .378 with two doubles, five homers and 10 RBI.  

The model also knows Milwaukee left fielder Christian Yelich enters the season healthy after having back surgery toward the end of the 2024 season. He has been the heart of the offense over the past seven seasons. In 73 games last year before being shut down, he hit .315 with 12 doubles, three triples, 11 homers and 42 RBI. 

The model has simulated Brewers vs. Yankees 10,000 times and the results are in. We can tell you the model is leaning Over on the run total, and it also says one side of the money line has ALL the value!

Who wins Brewers vs. Yankees, and which side of the money line has ALL the value? ... Join SportsLine right now to find out which side of the money line you should be all over, all from the model on a 32-17 roll on top-rated MLB picks!