Teams trending in opposite directions of late meet in an interleague matchup when the Toronto Blue Jays battle the Chicago Cubs on Friday afternoon. Toronto has won three in a row, while Chicago has dropped three straight.

First pitch is scheduled for 2:20 p.m. ET from Wrigley Field in Chicago. The Cubs are the -114 money-line favorites (risk $114 to win $100) in the latest Blue Jays vs. Cubs odds, while the Blue Jays are -105 underdogs. The over/under for total runs scored is 10 in the latest MLB odds via SportsLine consensus. 

Before you make any Blue Jays vs. Cubs picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. Entering Week 21 of the 2024 MLB season, it's on a 25-13 roll on top-rated run-line picks (+732). Anybody following has seen STRONG returns!

The model knows center fielder Cody Bellinger is among Chicago's top hitters. In 92 games this season, he is hitting .276 with 16 doubles, one triple, 12 homers and 46 RBI. In a 7-6 win over the Chicago White Sox on Aug. 9, he was 3-for-4 with a homer, two RBI and two run scored. He has hits in seven of the past 10 games. In six career games against the Blue Jays, he is batting .318 with three doubles, one homer and six RBI.

The model also knows first baseman Vladimir Guerrero Jr. is hitting .323 in 120 games, including 32 doubles, one triple, 25 homers and 80 RBI. He destroyed Los Angeles Angels pitching this week, going 6-for-14 with two homers and four RBI in a three-game series that finished up on Wednesday. He also had three hits with a double, triple, homer and four RBI in a 7-6 win over the Baltimore Orioles on Aug. 8.

The model has simulated Blue Jays vs. Royals 10,000 times and the results are in. We can tell you the model is leaning Under on the run total, and it also says one side of the money line has ALL the value!

Who wins Blue Jays vs. Cubs, and which side of the money line has ALL the value? ... Join SportsLine right now to find out which side of the money line you should be all over, all from the model on a 25-13 roll on top-rated MLB run-line picks!