The Buffalo Bills will look to solidify the No. 2 seed in the AFC playoff bracket when they battle the New England Patriots on Monday Night Football. Kickoff from Gillette Stadium in Foxborough, Mass., is set for 4:30 p.m. ET. Buffalo is favored by 7.5 points at William Hill Sportsbook, while the Over-Under is 47. Before making any Bills vs. Patriots picks, you NEED to check out the NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception five-plus years ago. It is a sizzling 22-11 on top-rated NFL picks this season, returning over $800. The model also enters Week 16 on an incredible 118-76 run on top-rated NFL picks that dates back to the 2017 season.

The model ranked in the Top 10 on NFLPickWatch three of the past four years on straight-up NFL picks and beat more than 95 percent of CBS Sports office pool players three times during that span. Anyone who has followed it is WAY UP.    

Now, it has set its sights on Bills vs. Patriots. We can tell you the model is leaning Over the total, and it also says one side of the spread cashes in more than 50 percent of simulations! You ABSOLUTELY need to see it before locking in any NFL picks.

Who wins Bills vs. Patriots on Monday Night Football? And which side of the spread cashes over half the time? ... Join SportsLine right now to find out which side of the Bills vs. Patriots spread you should be all over, all from the model on a 118-76 roll on NFL picks!