The Buffalo Bills will take on the Carolina Panthers at 1 p.m. ET on Sunday at Highmark Stadium. The Bills are 7-6 overall and 3-3 at home, while Carolina is 5-8 overall and 3-3 on the road.

Buffalo is favored by 14 points in the latest Bills vs. Panthers odds from Caesars Sportsbook, and the over-under is set at 44. Before you make any Panthers vs. Bills picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 15 of the 2021 season on an incredible 132-96 run on top-rated NFL picks that dates back to the 2017 season. The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY up.

Now, it has simulated Bills vs. Panthers 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also has generated a pick that hits in over 50 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Bills vs. Panthers? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks... If you're already a member, see the picks below!