The AFC East champion Buffalo Bills will seek their first postseason victory in 25 years when they host the Indianapolis Colts on Saturday in a Wild Card contest. Kickoff is set for 1:05 p.m. ET. Buffalo is a 6.5-point favorite in the latest odds from William Hill Sportsbook, while the Over/Under for total points scored is 51.5. (Check out the latest lines for every wild-card game on our NFL odds page.)

Before you make any Bills vs. Colts picks of your own, you NEED to hear what NFL and Indianapolis expert R.J. White has to say.

CBS Sports' fantasy and gambling editor, White enters the postseason on a sizzling 76-52-5 run on spread picks, returning $1,805. It's no surprise, as White has cashed huge twice in the world's most prestigious football handicapping competition, the Las Vegas SuperContest.

In addition White has gone an incredible 30-17-2 on his last 49 against-the-spread picks involving the Colts! Anyone who has followed him is WAY UP.

For Bills vs. Colts, we can tell you White is leaning Over the total, but his much stronger play is on the spread. In fact, White has found a crucial X-factor that has him going BIG on one side of the spread! You ABSOLUTELY need to see it before locking in your own picks.

Who wins Bills vs. Colts on Super Wild Card Weekend? And what crucial X-factor makes one side of the spread a MUST-BACK? ... Join SportsLine right now to see which side of the Bills vs. Colts spread you need to back, all from the acclaimed expert who's an astounding 30-17 on picks involving Indianapolis!