The top-seeded Kansas City Chiefs will host the No. 2 seed Buffalo Bills in Sunday's 2021 AFC Championship Game. Kickoff is set for 6:40 p.m. ET. William Hill Sportsbook lists Kansas City as a three-point favorite, while the over-under is 54.5 in the latest Chiefs-Bills odds. (Check out the latest odds for both playoffs games this weekend on our NFL odds page.)

Before you make any Bills vs. Chiefs picks, you NEED to see what SportsLine senior analyst and NFL expert Larry Hartstein has to say. 

A former lead writer for Covers and The Linemakers, Hartstein combines a vast network of Vegas sources with an analytical approach he honed while working for Pro Football Focus. In the 2019 season, he went 58-39 on his against-the-spread NFL picks, giving his followers a profit of more than $1,500. He heads into this weekend on a sizzling 22-10 (69 percent) run with his NFL point-spread picks for SportsLine members. 

What's more, Hartstein has his finger on the Chiefs' pulse, posting an eye-popping 16-2 record on against the spread picks involving the Chiefs! That includes nailing Cleveland +10 in last week's AFC divisional playoffs. Anyone who has consistently followed him is WAY UP!

Now, he's studied Bills vs. Chiefs from every possible angle. We can tell you he's leaning Over the total, and he's also found a critical X-factor that has him jumping ALL OVER one side of the spread! You ABSOLUTELY need to see it before you lock in your own picks.

So who wins Bills vs. Chiefs in the 2021 NFL Playoffs? And what critical X-factor makes one side of the spread a MUST-BACK? ... Join SportsLine right now to see which side of the Bills vs. Chiefs spread you need to bet RIGHT NOW, all from the seasoned expert who's 16-2 on picks involving Kansas City!