The Buffalo Bills (10-3) will visit the Denver Broncos (5-8) on Saturday afternoon. Kickoff is set for 4:30 p.m. ET at Empower Field at Mile High. Buffalo is a 5.5-point favorite in the latest Bills vs. Broncos odds at William Hill Sportsbook, while the Over-Under is 49 (For the latest NFL predictions for every game this week, check out our NFL odds page). 

Before making any Bills vs. Broncos picks, you NEED to check out the NFL predictions from the SportsLine Projection Model..

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception five-plus years ago. It is a sizzling 22-11 on top-rated NFL picks this season, returning over $800. The model also enters Week 15 on an incredible 118-76 run on top-rated NFL picks that dates back to the 2017 season.

The model ranked in the Top 10 on NFLPickWatch three of the past four years on straight-up NFL picks and beat more than 95 percent of CBS Sports office pool players three times during that span. Anyone who has followed it is WAY UP.

Now, it has set its sights on Bills vs. Broncos. We can tell you the model is leaning Under the total, and it also says one side of the spread cashes in well over 50 percent of simulations! You ABSOLUTELY need to see it before locking in any NFL picks.

Who wins Bills vs. Broncos on Saturday? And which side of the spread hits in well over 50 percent of simulations? ... Join SportsLine right now to find out which side of the Bills vs. Broncos spread you should be all over, all from the model on a 118-76 roll on NFL picks!